![]() Prospective Register of Systematic Reviews PRISMA, This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the article and its Supporting Information files.įunding: The author(s) received no specific funding for this work.Ĭompeting interests: The authors have declared that no competing interests exist. Received: NovemAccepted: Published: June 7, 2022Ĭopyright: © 2022 Ridjab et al. PLoS ONE 17(6):Įditor: Vincenzo Lionetti, Scuola Superiore Sant’Anna, ITALY We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement guidelines.Ĭitation: Ridjab DA, Ivan I, Budiman F, Tenggara R (2022) Evaluation of subclinical ventricular systolic dysfunction assessed using global longitudinal strain in liver cirrhosis: A systematic review, meta-analysis, and meta-regression. The study protocol was registered at PROSPERO (CRD42020201630). This research received no specific grants from any funding agency in the public, commercial, or not-for-profit sectors. Meta-regression analysis showed that the severity of cirrhosis was significantly related to GLS reduction. A sensitivity test on subgroup analysis based on the study design showed a -1.78% lower LV-GLS in the group with cirrhosis (I 2 = 70%, p = 0.0003). The systematic database search yielded 20 eligible studies. Publication bias was evaluated using Begg’s funnel plot, Egger’s test, and rank correlation test with subsequent trim-and-fill analysis. Meta-analyses were conducted with subsequent sensitivity and subgroup analyses according to age, sex, cirrhosis etiology, and severity. The Newcastle Ottawa Scale was used to assess the quality of nonrandomized studies. Studies from inception to August 11, 2021, were screened and included based on the inclusion criteria. This systematic review aims to provide evidence of a possible difference in GLS values between patients with cirrhosis and patients without cirrhosis. Global longitudinal strain (GLS) can identify subclinical myocardial dysfunction in patients with cirrhosis.
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